TC-DAPK 6

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TC-DAPK 6 是一种有效的ATP竞争性的选择性 DAPK 抑制剂，作用于 DAPK1 和 DAPK3，IC50 分别为 69 和 225 nM。

TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP).

TC-DAPK 6 is found to be the most potent Death-associated protein kinase (DAPK) inhibitor with enzyme selectivity. When assayed with 10 μM ATP, the IC50 values for DAPK1 and DAPK3 are 69 and 225 nM, respectively. TC-DAPK 6 also inhibits p70S6K (1 μM < IC50< 10 μM).

——

——

Apoptosis

DAPK

DAPK

——

——

315694-89-4

276.29

C17H12N2O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 18.67 mg/mL (67.57 mM; 超声加热助溶 )

C(=C1C(=O)OC(C=CC2=CC=CC=C2)=N1)C=3C=CC=NC3

——

(-20℃)

With Ice Pack

≥ 2 years